Pyruvate Dehydrogenase Complex

A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)

Also Known As:

Dehydrogenase Complex, Pyruvate; Complex, Pyruvate Dehydrogenase

Macromolecular Substances: 97
- Multiprotein Complexes: 125
  - Multienzyme Complexes: 8
    - Pyruvate Dehydrogenase Complex: 432
Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Multienzyme Complexes: 8
    - Pyruvate Dehydrogenase Complex: 432

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Drug/Important Bio-Agent (IBA)